Introduction :
Hepatitis B is a global health concern, affecting many people around the world. While there are medical treatments available, some patients turn to complementary and alternative medicine for additional support. One intriguing natural remedy that has caught the attention of researchers is the extract of the Agaricus Blazei Murill (ABM) mushroom. In this blog, we’ll break down the findings of a clinical trial that explored how ABM extract might play a role in normalizing liver function in patients with chronic hepatitis B.
Understanding Hepatitis B :
Hepatitis B is a viral infection that primarily affects the liver. It can cause a range of symptoms, from mild illness to severe liver damage. People with chronic hepatitis B often experience inflammation of the liver, which can lead to liver function abnormalities.
Hepatitis C Cases Worldwide and Common Symptoms :
Hepatitis C is a significant global health concern, affecting millions of people worldwide. According to the World Health Organization (WHO), it’s estimated that around 71 million people are living with chronic hepatitis C infection globally. This viral infection primarily targets the liver and can lead to both acute and chronic forms of the disease.
The symptoms of hepatitis C can vary, and many individuals with the infection may not experience noticeable symptoms initially. However, common symptoms can include fatigue, jaundice (yellowing of the skin and eyes), dark urine, abdominal pain, and loss of appetite. Chronic hepatitis C can lead to severe liver damage over time, often progressing silently until complications arise. Regular screening and early detection are crucial for managing the disease effectively and preventing long-term liver damage. It’s essential to consult a healthcare professional for proper diagnosis and treatment if you suspect you may have been exposed to hepatitis C or are experiencing symptoms.
The Clinical Trial :
This study was an open-label pilot study conducted over 12 months, involving patients with chronic hepatitis B. The inclusion criteria for the study were specific: participants had to be between 20 and 65 years old, of Chinese ethnicity, carriers of the hepatic B antigen (HBAg(+)) for over three years, have high levels of alanine aminotransferase (a liver enzyme), and not be taking certain medications for hepatitis.
The enrolled patients were given a daily dose of 1500 mg of Agaricus Blazei Murill (ABM) extract for 12 months. The major outcome measurement was the level of alanine aminotransferase.
The Results :
At the end of the 12-month study, the results were promising. The levels of two important liver enzymes, aspartate aminotransferase and alanine aminotransferase, showed significant improvements. Aspartate aminotransferase levels decreased from 246.0 to 61.3 IU/L, while alanine aminotransferase levels decreased from 151.0 to 46.1 IU/L.
Understanding Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) :
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are essential enzymes produced by the liver. These enzymes play a critical role in assessing liver health. When the liver is damaged or experiencing inflammation, as often seen in conditions like hepatitis B, these enzymes can leak into the bloodstream, causing their levels to rise.
- AST: This enzyme, also known as SGOT (serum glutamic oxaloacetic transaminase), is primarily found in the liver, heart, muscles, and other organs. An elevated AST level may indicate liver damage, but it’s important to note that high levels can also be related to heart issues or muscle damage. Therefore, AST is a valuable marker in diagnosing and monitoring liver conditions, as well as other health concerns.
- ALT: Often referred to as SGPT (serum glutamic pyruvic transaminase), ALT is primarily concentrated in the liver. Like AST, elevated ALT levels in the bloodstream can be a sign of liver damage. It’s a more liver-specific marker and is often used to detect liver conditions, especially hepatitis. Monitoring ALT levels is crucial in evaluating liver function and assessing the impact of liver diseases.
In the context of the clinical trial with ABM extract, the significant reduction in both AST and ALT levels observed at the end of the study is an encouraging sign. It indicates an improvement in liver function, suggesting that ABM extract may have a positive impact on patients with chronic hepatitis B. However, it’s important to remember that these enzymes are just a part of the larger picture of liver health, and their levels should be interpreted in consultation with healthcare professionals.
What Does This Mean? :
These findings suggest that ABM extract may have the potential to improve liver function in patients with chronic hepatitis B. While this pilot study showed promise, it’s important to note that larger, controlled studies are needed to confirm these results. This is just the first step in exploring the possible benefits of ABM extract for liver health.
In the world of natural remedies, Agaricus Blazei Murill mushrooms are showing potential in supporting liver function. As more research unfolds, we may discover new ways to complement existing treatments for hepatitis B. Always consult with your healthcare provider before trying any new treatments, especially if you have a medical condition.
Hepatitis B is a serious condition, and it’s crucial to work closely with your medical team to find the best approach for your specific situation. In the meantime, keep an eye on the exciting developments in the world of medicinal mushrooms, as they continue to reveal their potential benefits for our health.
Bibliography :
- Chung-Hua Hsu, Kung-Chang Hwang, Yi-Hsiung Chiang, Pesus Chou. (2008). The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. J Altern Complement Med, 14(3), 299-301. DOI: 10.1089/acm.2006.6344. PMID: 18370584.