COVID-19

Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation?
Geir Hetland 1 2, Egil Johnson 2 3, Soosaipillai V Bernardshaw 4, Bjørn Grinde 5
PMID: 32657436 DOI: 10.1111/sji.12937

Anti-inflammatory

Agaricus blazei Murrill Polysaccharide Attenuates Periodontitis via H2 S/NRF2 Axis-Boosted Appropriate Level of Autophagy in PDLCs.
Yuan W, Huang M, Wu Y, Liu J, Zhou X, Wang J, Liu J. Mol Nutr Food Res. 2023 Sep 29:e2300112. doi: 10.1002/mnfr.202300112. Online ahead of print. PMID: 37775336

Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies. Hetland G, Tangen JM, Mahmood F, Mirlashari MR, Nissen-Meyer LSH, Nentwich I, Therkelsen SP, Tjønnfjord GE, Johnson E. Nutrients. 2020 May 8;12(5):E1339. doi: 10.3390/nu12051339. PMID: 32397163

The anti-inflammatory effect of Agaricus brasiliensis is partly due to its linoleic acid content. Saiki P, Kawano Y, Van Griensven LJLD, Miyazaki K. Food Funct. 2017 Oct 12. PMID: 29022634

Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash Through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver. Nakamura A, Zhu Q, Yokoyama Y, Kitamura N, Uchida S, Kumadaki K, Tsubota K, Watanabe M Foods. 2019 Nov 4;8(11). pii: E546. doi: 10.3390/foods8110546. PMID: 31689883

Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash Through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver. Nakamura A, Zhu Q, Yokoyama Y, Kitamura N, Uchida S, Kumadaki K, Tsubota K, Watanabe M Foods. 2019 Nov 4;8(11). pii: E546. doi: 10.3390/foods8110546. PMID: 31689883

Sepsis

Agaricus brasiliensis Mushroom Protects Against Sepsis by Alleviating Oxidative and Inflammatory Response. Navegantes-Lima KC, Monteiro VVS, de França Gaspar SL, de Brito Oliveira AL, de Oliveira JP, Reis JF, de Souza Gomes R, Rodrigues CA, Stutz H, Sovrani V, Peres A, Romão PRT, Monteiro MC. Front Immunol. 2020 Jul 1;11:1238. doi: 10.3389/fimmu.2020.01238. eCollection 2020. PMID: 32714320