Antioxidant Activity of Mushroom Extracts/Polysaccharides-Their Antiviral Properties and Plausible AntiCOVID-19 Properties.
Chun S, Gopal J, Muthu M. Antioxidants (Basel). 2021 Nov 26;10(12):1899. doi: 10.3390/antiox10121899. PMID: 34943001

Assessment of antioxidant and antidiabetic properties of Agaricus blazei Murill extracts. Wei Q, Zhan Y, Chen B, Xie B, Fang T, Ravishankar S, Jiang Y. Food Sci Nutr. 2019 Dec 5;8(1):332-339. doi: 10.1002/fsn3.1310. eCollection 2020 Jan. PMID: 31993159

Effects of Fungal Polysaccharide on Oxidative Damage and TLR4 Pathway to the Central Immune Organs in Cadmium Intoxication in Chickens. Li R, Zhang L, Tang Z, Li T, Li G, Zhang R, Ge M. Biol Trace Elem Res. 2019 Jan 10. doi: 10.1007/s12011-018-1627-0. 

A natural food ingredient based on ergosterol: optimization of the extraction from Agaricus blazei, evaluation of bioactive properties and incorporation in yogurts.Corrêa RCG, Barros L, Fernandes Â, Sokovic M, Bracht A, Peralta RM, Ferreira ICFR. Food Funct. 2018 Mar 1;9(3):1465-1474. doi: 10.1039/c7fo02007d. Epub 2018 Feb 28. PMID: 29488518

Protective Effect of Agaricus blazei Polysaccharide Against Cadmium-Induced Damage on the Testis of Chicken.Song Y, Zhang R, Wang H, Yan Y, Ming G. Biol Trace Elem Res. 2017 Nov 10. doi: 10.1007/s12011-017-1196-7. [Epub ahead of print] PMID: 29127548

Agaricus blazei Murill Polysaccharides Protect Against Cadmium-Induced Oxidative Stress and Inflammatory Damage in Chicken Spleens.Xie W, Lv A, Li R, Tang Z, Ma D, Huang X, Zhang R, Ge M. Biol Trace Elem Res. 2017 Oct 14. doi: 10.1007/s12011-017-1189-6. [Epub ahead of print] PMID: 29032405

Effects of Agaricus blazei Murill Polysaccharide on Cadmium Poisoning on the MDA5 Signaling Pathway and Antioxidant Function of Chicken Peripheral Blood Lymphocytes.Lv A, Ge M, Hu X, Liu W, Li G, Zhang R. Biol Trace Elem Res. 2018 Jan;181(1):122-132. doi: 10.1007/s12011-017-1012-4. Epub 2017 Apr 21. PMID: 28432527

Antigenotoxic Properties of Agaricus blazei against Hydrogen Peroxide in Human Peripheral Blood Cells.Živković L, Borozan S, Čabarkapa A, Topalović D, Ciptasari U, Bajić V, Spremo-Potparević B. Oxid Med Cell Longev. 2017;2017:8759764. doi: 10.1155/2017/8759764. Epub 2017 Feb 21. PMID: 28316757

The Protective Effects of Polysaccharides from Agaricus blazei Murill Against Cadmium-Induced Oxidant Stress and Inflammatory Damage in Chicken Livers.Hu X, Zhang R, Xie Y, Wang H, Ge M. Biol Trace Elem Res. 2017 Jul;178(1):117-126. doi: 10.1007/s12011-016-0905-y. Epub 2016 Dec 9. PMID: 27943028

Agaricus blazei extract attenuates rotenone-induced apoptosis through its mitochondrial protective and antioxidant properties in SH-SY5Y neuroblastoma cells.Venkatesh Gobi V, Rajasankar S, Ramkumar M, Dhanalakshmi C, Manivasagam T, Justin Thenmozhi A, Essa MM, Chidambaram R. Nutr Neurosci. 2018 Feb;21(2):97-107. doi: 10.1080/1028415X.2016.1222332. Epub 2016 Sep 20. PMID: 27646574

Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria.Val CH, Brant F, Miranda AS, Rodrigues FG, Oliveira BC, Santos EA, Assis DR, Esper L, Silva BC, Rachid MA, Tanowitz HB, Teixeira AL, Teixeira MM, Régis WC, Machado FS. Malar J. 2015 Aug 11;14:311. doi: 10.1186/s12936-015-0832-y. PMID: 26260055

Effects of selenium-enriched Agaricus blazei Murill on liver metabolic dysfunction in mice, a comparison with selenium-deficient Agaricus blazei Murill and sodium selenite.Yu L, Yang S, Sun L, Jiang YF, Zhu LY. Biol Trace Elem Res. 2014 Jul;160(1):79-84. doi: 10.1007/s12011-014-0022-8. Epub 2014 Jun 8. PMID: 24908110

Anti-Inflammatory Activity of Water-Soluble Polysaccharide of Agaricus blazei Murill on Ovariectomized Osteopenic Rats.Wang P, Li XT, Sun L, Shen L. Evid Based Complement Alternat Med. 2013;2013:164817. doi: 10.1155/2013/164817. Epub 2013 Nov 24. PMID: 24348690

Effects of an Agaricus blazei aqueous extract pretreatment on paracetamol-induced brain and liver injury in rats.Soares AA, de Oliveira AL, Sá-Nakanishi AB, Comar JF, Rampazzo AP, Vicentini FA, Natali MR, Gomes da Costa SM, Bracht A, Peralta RM. Biomed Res Int. 2013;2013:469180. doi: 10.1155/2013/469180. Epub 2013 Jul 25. PMID: 23984368

Chemical, enzymatic and cellular antioxidant activity studies of Agaricus blazei Murrill.Hakime-Silva RA, Vellosa JC, Khalil NM, Khalil OA, Brunetti IL, Oliveira OM. An Acad Bras Cienc. 2013 Sep;85(3):1073-81. doi: 10.1590/S0001-37652013005000044. Epub 2013 Aug 13. PMID: 23969852

Agaricus blazei Murill as an efficient hepatoprotective and antioxidant agent against CCl4-induced liver injury in rats.Al-Dbass AM, Al-Daihan SK, Bhat RS. Saudi J Biol Sci. 2012 Jul;19(3):303-9. doi: 10.1016/j.sjbs.2012.03.004. Epub 2012 Apr 1. PMID: 23961190

Chemical composition and antioxidant activity of dried powder formulations of Agaricus blazei and Lentinus edodes.Carneiro AA, Ferreira IC, Dueñas M, Barros L, da Silva R, Gomes E, Santos-Buelga C. Food Chem. 2013 Jun 15;138(4):2168-73. doi: 10.1016/j.foodchem.2012.12.036. Epub 2012 Dec 29. PMID: 23497872

Therapeutic efficacy induced by the oral administration of Agaricus blazei Murill against Leishmania amazonensis.Valadares DG, Duarte MC, Ramírez L, Chávez-Fumagalli MA, Lage PS, Martins VT, Costa LE, Ribeiro TG, Régis WC, Soto M, Fernandes AP, Tavares CA, Coelho EA. Parasitol Res. 2012 Oct;111(4):1807-16. Epub 2012 Jul 15. PMID: 22797606

Leishmanicidal activity of the Agaricus blazei Murill in different Leishmania species.Valadares DG, Duarte MC, Oliveira JS, Chávez-Fumagalli MA, Martins VT, Costa LE, Leite JP, Santoro MM, Régis WC, Tavares CA, Coelho EA. Parasitol Int. 2011 Dec;60(4):357-63. doi: 10.1016/j.parint.2011.06.001. Epub 2011 Jun 24. PMID: 21723957

Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats.Niwa A, Tajiri T, Higashino H. J Clin Biochem Nutr. 2011 May;48(3):194-202. doi: 10.3164/jcbn.10-78. Epub 2011 Jan 7. PMID: 21562638

Agaricus blazei Murill extract abrogates CCl4-induced liver injury in rats.Wu MF, Hsu YM, Tang MC, Chen HC, Chung JG, Lu HF, Lin JP, Tang NY, Yeh C, Yeh MY. In Vivo. 2011 Jan-Feb;25(1):35-40. PMID: 21282732

Antioxidant Activity of Agaricus brasiliensis Basidiocarps on Different Maturation Phases.Mourão F, Harue Umeo S, Seiko Takemura O, Andrea Linde G, Barros Colauto N. Braz J Microbiol. 2011 Jan;42(1):197-202. doi: 10.1590/S1517-83822011000100024. PMID: 24031621

Effect of Agaricus blazei Murill on the pulmonary tissue of animals with streptozotocin-induced diabetes.Di Naso FC, de Mello RN, Bona S, Dias AS, Porawski M, Ferraz Ade B, Richter MF, Marroni NP. Exp Diabetes Res. 2010;2010:543926. doi: 10.1155/2010/543926. Epub 2010 May 26. PMID: 20585363

Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: can effects be explained by structure?Volman JJ, Helsper JP, Wei S, Baars JJ, van Griensven LJ, Sonnenberg AS, Mensink RP, Plat J. Mol Nutr Food Res. 2010 Feb;54(2):268-76. doi: 10.1002/mnfr.200900009. PMID: 19885842

Effect of an extract based on the medicinal mushroom Agaricus blazei murill on release of cytokines, chemokines and leukocyte growth factors in human blood ex vivo and in vivo.Johnson E, Førland DT, Saetre L, Bernardshaw SV, Lyberg T, Hetland G. Scand J Immunol. 2009 Mar;69(3):242-50. doi: 10.1111/j.1365-3083.2008.02218.x. PMID: 19281536

 Antioxidative and antimutagenic activities of 70% ethanolic extracts from four fungal mycelia-fermented specialty rices.Ra Yoon M, Hyun Nam S, Young Kang M. J Clin Biochem Nutr. 2008 Sep;43(2):118-25. doi: 10.3164/jcbn.2008056. PMID: 18818745

Tumoricidal effects of beta-glucans: mechanisms include both antioxidant activity plus enhanced systemic and topical immunity.Gu Y, Fujimiya Y, Itokawa Y, Oshima M, Choi JS, Miura T, Ishida T. Nutr Cancer. 2008;60(5):685-91. doi: 10.1080/01635580802030884. PMID: 18791933

Lack of carcinogenicity of lyophilized Agaricus blazei Murill in a F344 rat two year bioassay.Lee IP, Kang BH, Roh JK, Kim JR. Food Chem Toxicol. 2008 Jan;46(1):87-95. Epub 2007 Jul 13. PMID: 17707568

Antioxidant activity of Agaricus blazei.Oliveira OM, Vellosa JC, Fernandes AS, Buffa-Filho W, Hakime-Silva RA, Furlan M, Brunetti IL. Fitoterapia. 2007 Apr;78(3):263-4. Epub 2007 Feb 6. PMID: 17349751

Antioxidant capability of polysaccharides fractionated from submerge-cultured Agaricus blazei mycelia.Ker YB, Chen KC, Chyau CC, Chen CC, Guo JH, Hsieh CL, Wang HE, Peng CC, Chang CH, Peng RY. J Agric Food Chem. 2005 Sep 7;53(18):7052-8. PMID: 16131110

A screening system for antioxidants using thioredoxin-deficient yeast: discovery of thermostable antioxidant activity from Agaricus blazei Murill.Izawa S, Inoue Y. Appl Microbiol Biotechnol. 2004 May;64(4):537-42. Epub 2003 Oct 31. PMID: 14593506

Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash Through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver. Nakamura A, Zhu Q, Yokoyama Y, Kitamura N, Uchida S, Kumadaki K, Tsubota K, Watanabe M Foods. 2019 Nov 4;8(11). pii: E546. doi: 10.3390/foods8110546. PMID: 31689883


Agaricus brasiliensis Mushroom Protects Against Sepsis by Alleviating Oxidative and Inflammatory Response. Navegantes-Lima KC, Monteiro VVS, de França Gaspar SL, de Brito Oliveira AL, de Oliveira JP, Reis JF, de Souza Gomes R, Rodrigues CA, Stutz H, Sovrani V, Peres A, Romão PRT, Monteiro MC. Front Immunol. 2020 Jul 1;11:1238. doi: 10.3389/fimmu.2020.01238. eCollection 2020. PMID: 32714320