Anti-Viral

Tissue invasion and metastasis: Molecular, biological and clinical perspectives. Jiang WG, Sanders AJ, Katoh M, Ungefroren H, Gieseler F, Prince M, Thompson SK, Zollo M, Spano D, Dhawan P, Sliva D, Subbarayan PR, Sarkar M, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Ye L, Helferich WG, Yang X, Boosani CS, Guha G, Ciriolo MR, Aquilano K, Chen S, Azmi AS, Keith WN, Bilsland A, Bhakta D, Halicka D, Nowsheen S, Pantano F, Santini D. Semin Cancer Biol. 2015 Dec;35 Suppl:S244-S275. doi: 10.1016/j.semcancer.2015.03.008. Epub 2015 Apr 10. Review. PMID: 25865774

Extract from Agaricus blazei Murill can enhance immune responses elicited by DNA vaccine against foot-and-mouth disease. Chen L, Shao H. Vet Immunol Immunopathol. 2006 Jan 15;109(1-2):177-82. Epub 2005 Oct 6. PMID:16213597

Inhibition by Agaricus blazei Murill fractions of cytopathic effect induced by western equine encephalitis (WEE) virus on VERO cells in vitro. Sorimachi K, Ikehara Y, Maezato G, Okubo A, Yamazaki S, Akimoto K, Niwa A. Biosci Biotechnol Biochem. 2001 Jul;65(7):1645-7. PMID: 11515550

Hepatitis

The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. Hsu CH, Hwang KC, Chiang YH, Chou P. J Altern Complement Med. 2008 Apr;14(3):299-301. doi: 10.1089/acm.2006.6344. PMID: 18370584

Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection. Grinde B, Hetland G, Johnson E.mInt Immunopharmacol. 2006 Aug;6(8):1311-4. Epub 2006 May 11. PMID: 16782544

Coimmunization of Agaricus blazei Murill extract with hepatitis B virus core protein through DNA vaccine enhances cellular and humoral immune responses. Chen L, Shao HJ, Su YB. Int Immunopharmacol. 2004 Mar;4(3):403-9. PMID:15037217 

Herpes

Antiherpetic mechanism of a sulfated derivative of Agaricus brasiliensis fruiting bodies polysaccharide. Cardozo FT, Camelini CM, Leal PC, Kratz JM, Nunes RJ, Mendonça MM, Simões CM. Intervirology. 2014;57(6):375-83. doi: 10.1159/000365194. Epub 2014 Oct 25. PMID: 25359160

In vivo anti-herpes simplex virus activity of a sulfated derivative of Agaricus brasiliensis mycelial polysaccharide. Cardozo FT, Larsen IV, Carballo EV, Jose G, Stern RA, Brummel RC, Camelini CM, Rossi MJ, Simões CM, Brandt CR. Antimicrob Agents Chemother. 2013 Jun;57(6):2541-9. doi: 10.1128/AAC.02250-12. Epub 2013 Mar 18. PMID: 23507287

Antiherpetic activity of an Agaricus brasiliensis polysaccharide, its sulfated derivative and fractions. Yamamoto KA, Galhardi LC, Rincão VP, Soares Sde A, Vieira IG, Ricardo NM, Nozawa C, Linhares RE. Int J Biol Macromol. 2013 Jan;52:9-13. doi: 10.1016/j.ijbiomac.2012.09.029. Epub 2012 Oct 5. PMID: 23043759

Antiviral properties of polysaccharides from Agaricus brasiliensis in the replication of bovine herpesvirus 1. Minari MC, Rincão VP, Soares SA, Ricardo NM, Nozawa C, Linhares RE. Acta Virol. 2011;55(3):255-9. PMID: 21978159

Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia. Cardozo FT, Camelini CM, Mascarello A, Rossi MJ, Nunes RJ, Barardi CR, de Mendonça MM, Simões CM. Antiviral Res. 2011 Oct;92(1):108-14. doi: 10.1016/j.antiviral.2011.07.009. Epub 2011 Jul 20. PMID: 21787804

Poliovirus

Antiviral activity of aqueous and ethanol extracts and of an isolated polysaccharide from Agaricus brasiliensis against poliovirus type 1. Faccin LC, Benati F, Rincão VP, Mantovani MS, Soares SA, Gonzaga ML, Nozawa C, Carvalho Linhares RE. Lett Appl Microbiol. 2007 Jul;45(1):24-8. PMID: 17594456