Alzheimers

The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore. Feng Lei, Irwin Kee-Mun Cheah, Rahul Malhotra, Ee-Heok Kua, and Tze-Pin Ng. (. Journal of Alzheimer’s Disease, 68(1).2019) doi: 10.3233/JAD-180959.

Antidepressant - Mental Health

Antidepressant Effect of Water Extract of Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Agaricomycetes), in Mice Exposed to Chronic Unpredictable Mild Stress.
Xin Y, Zhang Y, Zhang X. Int J Med Mushrooms. 2022;24(4):63-73. doi: 10.1615/IntJMedMushrooms.2022042726. PMID: 35695597

Brain

Agaricus blazei extract abrogates rotenone-induced dopamine depletion and motor deficits by its anti-oxidative and anti-inflammatory properties in Parkinsonic mice. Venkatesh Gobi V, Rajasankar S, Ramkumar M, Dhanalakshmi C, Manivasagam T, Justin Thenmozhi A, Essa MM, Chidambaram R, Kalandar A. Nutr Neurosci. 2017 Jun 19:1-10. doi: 10.1080/1028415X.2017.1337290. [Epub ahead of print] PMID: 28628424

Agaricus blazei extract attenuates rotenone-induced apoptosis through its mitochondrial protective and antioxidant properties in SH-SY5Y neuroblastoma cells. Venkatesh Gobi V, Rajasankar S, Ramkumar M, Dhanalakshmi C, Manivasagam T, Justin Thenmozhi A, Essa MM, Chidambaram R. Nutr Neurosci. 2018 Feb;21(2):97-107. doi: 10.1080/1028415X.2016.1222332. Epub 2016 Sep 20. PMID: 27646574

Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria. Val CH, Brant F, Miranda AS, Rodrigues FG, Oliveira BC, Santos EA, Assis DR, Esper L, Silva BC, Rachid MA, Tanowitz HB, Teixeira AL, Teixeira MM, Régis WC, Machado FS. Malar J. 2015 Aug 11;14:311. doi: 10.1186/s12936-015-0832-y. PMID: 26260055

Effects of the continuous administration of an Agaricus blazei extract to rats on oxidative parameters of the brain and liver during aging. de Sá-Nakanishi AB, Soares AA, Natali MR, Comar JF, Peralta RM, Bracht A. Molecules. 2014 Nov 13;19(11):18590-603. doi: 10.3390/molecules191118590. PMID: 25401401

Effects of treating old rats with an aqueous Agaricus blazei extract on oxidative and functional parameters of the brain tissue and brain mitochondria. de Sá-Nakanishi AB, Soares AA, de Oliveira AL, Comar JF, Peralta RM, Bracht A. Oxid Med Cell Longev. 2014;2014:563179. doi: 10.1155/2014/563179. Epub 2014 Apr 28. PMID: 24876914