Leukemia/Myeloma

Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™. Tangen JM, Holien T, Mirlashari MR, Misund K, Hetland G. Biomed Res Int. 2017;2017:2059825. doi: 10.1155/2017/2059825. Epub 2017 Nov 7. PMID: 29238712

A polysaccharide from the fruiting bodies of Agaricus blazei Murill induces caspase-dependent apoptosis in human leukemia HL-60 cells. Li X, Zhao X, Wang H, Han J, Liu L. Tumour Biol. 2014 Sep;35(9):8963-8. doi: 10.1007/s13277-014-2137-0. Epub 2014 Jun 6. PMID: 24903379

An extract of Agaricus blazei Murill administered orally promotes immune responses in murine leukemia BALB/c mice in vivo. Lin JG, Fan MJ, Tang NY, Yang JS, Hsia TC, Lin JJ, Lai KC, Wu RS, Ma CY, Wood WG, Chung JG. Integr Cancer Ther. 2012 Mar;11(1):29-36. doi: 10.1177/1534735411400314. PMID: 22637937

Agaritine from Agaricus blazei Murrill induces apoptosis in the leukemic cell line U937. Akiyama H, Endo M, Matsui T, Katsuda I, Emi N, Kawamoto Y, Koike T, Beppu H. Biochim Biophys Acta. 2011 May;1810(5):519-25. doi: 10.1016/j.bbagen.2011.02.010. Epub 2011 Mar 5. PMID: 21382445

Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells. Endo M, Beppu H, Akiyama H, Wakamatsu K, Ito S, Kawamoto Y, Shimpo K, Sumiya T, Koike T, Matsui T. Biochim Biophys Acta. 2010 Jul;1800(7):669-73. doi: 10.1016/j.bbagen.2010.03.016. Epub 2010 Mar 27. PMID: 20347942

Inhibitory effects of Agaricus blazei extracts on human myeloid leukemia cells. Kim CF, Jiang JJ, Leung KN, Fung KP, Lau CB. J Ethnopharmacol. 2009 Mar 18;122(2):320-6. doi: 10.1016/j.jep.2008.12.025. Epub 2008 Dec 27. PMID: 19162153

Primary mechanism of apoptosis induction in a leukemia cell line by fraction FA-2-b-ss prepared from the mushroom Agaricus blazei Murill. Gao L, Sun Y, Chen C, Xi Y, Wang J, Wang Z. Braz J Med Biol Res. 2007 Nov;40(11):1545-55. PMID: 17934651

Therapy of myeloma in vivo using marine phospholipid in combination with Agaricus blazei Murill as an immune respond activator. Murakawa K, Fukunaga K, Tanouchi M, Hosokawa M, Hossain Z, Takahashi K. J Oleo Sci. 2007;56(4):179-88. PMID: 17898480

Bcl-2 and caspase-3 are major regulators in Agaricus blazei-induced human leukemic U937 cell apoptosis through dephoshorylation of Akt. Jin CY, Moon DO, Choi YH, Lee JD, Kim GY. Biol Pharm Bull. 2007 Aug;30(8):1432-7. PMID: 17666799