Liver

Possible reduction of hepatoma formation by Smmu 7721 cells in SCID mice and metastasis formation by B16F10 melanoma cells in C57BL/6 mice by Agaricus blazei murill extract. Wu MF, Lu HF, Hsu YM, Tang MC, Chen HC, Lee CS, Yang YY, Yeh MY, Chung HK, Huang YP, Wu CC, Chung JG. In Vivo. 2011 May-Jun;25(3):399-404. PMID: 21576414

Blazeispirol A from Agaricus blazei fermentation product induces cell death in human hepatoma Hep 3B cells through caspase-dependent and caspase-independent pathways. Su ZY, Tung YC, Hwang LS, Sheen LY. J Agric Food Chem. 2011 May 11;59(9):5109-16. doi: 10.1021/jf104700j. Epub 2011 Mar 28. PMID: 21417302

Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NFκB-mediated increase of intracellular doxorubicin accumulation. Lee JS, Hong EK. Int J Oncol. 2011 Feb;38(2):401-8. doi: 10.3892/ijo.2010.852. Epub 2010 Dec 3. PMID: 21132265

Agaricus blazei Murill extract abrogates CCl4-induced liver injury in rats. Wu MF, Hsu YM, Tang MC, Chen HC, Chung JG, Lu HF, Lin JP, Tang NY, Yeh C, Yeh MY. In Vivo. 2011 Jan-Feb;25(1):35-40. PMID: 21282732

Effects of Agaricus brasiliensis mushroom in Walker-256 tumor-bearing rats. Jumes FM, Lugarini D, Pereira AL, de Oliveira A, Christoff Ade O, Linde GA, do Valle JS, Colauto NB, Acco A. Can J Physiol Pharmacol. 2010 Jan;88(1):21-7. doi: 10.1139/Y09-111. PMID: 20130735

Beta-glucan extracted from the medicinal mushroom Agaricus blazei prevents the genotoxic effects of benzo[a]pyrene in the human hepatoma cell line HepG2. Angeli JP, Ribeiro LR, Bellini MF, Mantovani MS. Arch Toxicol. 2009 Jan;83(1):81-6. doi: 10.1007/s00204-008-0319-5. Epub 2008 Jun 5. PMID: 18528685

IL-12 Production Induced by Agaricus blazei Fraction H (ABH) Involves Toll-like Receptor (TLR). Kasai H, He LM, Kawamura M, Yang PT, Deng XW, Munkanta M, Yamashita A, Terunuma H, Hirama M, Horiuchi I, Natori T, Koga T, Amano Y, Yamaguchi N, Ito M. Evid Based Complement Alternat Med. 2004 Dec;1(3):259-267. PMID: 15841259

Chemoprevention of preneoplastic liver foci development by dietary mushroom Agaricus blazei Murrill in the rat. Pinheiro F, Faria RR, de Camargo JL, Spinardi-Barbisan AL, da Eira AF, Barbisan LF. Food Chem Toxicol. 2003 Nov;41(11):1543-50. PMID: 12963007

Effects of crude extracts of Agaricus blazei on DNA damage and on rat liver carcinogenesis induced by diethylnitrosamine. Barbisan LF, Scolastici C, Miyamoto M, Salvadori DM, Ribeiro LR, da Eira AF, de Camargo JL. Genet Mol Res. 2003 Sep 30;2(3):295-308. PMID: 14966678

Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamine. Barbisan LF, Miyamoto M, Scolastici C, Salvadori DM, Ribeiro LR, Eira AF, de Camargo JL. J Ethnopharmacol. 2002 Nov;83(1-2):25-32. PMID: 12413704

Inhibitory action of a (1–>6)-beta-D-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murill (“himematsutake”) on Meth A fibrosarcoma-bearing mice and its antitumor mechanism. Itoh H, Ito H, Amano H, Noda H. Jpn J Pharmacol. 1994 Oct;66(2):265-71. PMID: 7869611