Breast

Effects of sulfated and non-sulfated β-glucan extracted from Agaricus brasiliensis in breast adenocarcinoma cells – MCF-7. Baranoski A, Tempesta Oliveira M, Semprebon SC, Niwa AM, Ribeiro LR, Mantovani MS. Toxicol Mech Methods. 2015 Nov;25(9):672-9. doi: 10.3109/15376516.2015.1043762. Epub 2015 May 13. PMID: 25970150

Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricus blazei mycelia. Dong S, Furutani Y, Kimura S, Zhu Y, Kawabata K, Furutani M, Nishikawa T, Tanaka T, Masaki T, Matsuoka R, Kiyama R. J Agric Food Chem. 2013 Jan 9;61(1):128-36. doi: 10.1021/jf304546a. Epub 2012 Dec 20. PMID: 23215459

Agaricus blazei (class Basidiomycotina) aqueous extract enhances the expression of c-Jun protein in MCF7 cells. Talorete TP, Isoda H, Maekawa T. J Agric Food Chem. 2002 Aug 28;50(18):5162-6. PMID: 12188624

Medicinal Properties and Clinical Effects of Culinary-Medicinal Mushroom Agaricus blazei Murrill (Agaricomycetideae) (Review) Takashi Mizuno  Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 4-13-9 Seinan-Cho, Fujieda-Shi 426-0063, Japan International Journal of Medicinal  Mushrooms DOI:10.1615/IntJMedMushr.v4.i4.30

Ovarian / Gynecological 

Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model. Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yagyu T, Inagaki K, Kondo T, Kurita N, Suzuki M, Kanayama N, Terao T. J Cancer Res Clin Oncol. 2005 Aug;131(8):527-38. Epub 2005 May 10. PMID: 15883813

Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP. Int J Gynecol Cancer. 2004 Jul-Aug;14(4):589-94. PMID: 15304151 [PubMed – indexed for MEDLINE]

Prostate

Tissue invasion and metastasis: Molecular, biological and clinical perspectives. Jiang WG, Sanders AJ, Katoh M, Ungefroren H, Gieseler F, Prince M, Thompson SK, Zollo M, Spano D, Dhawan P, Sliva D, Subbarayan PR, Sarkar M, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Ye L, Helferich WG, Yang X, Boosani CS, Guha G, Ciriolo MR, Aquilano K, Chen S, Azmi AS, Keith WN, Bilsland A, Bhakta D, Halicka D, Nowsheen S, Pantano F, Santini D. Semin Cancer Biol. 2015 Dec;35 Suppl:S244-75. doi: 10.1016/j.semcancer.2015.03.008. Epub 2015 Apr 10. Review.PMID: 25865774

Inhibitory mechanisms of Agaricus blazei Murill on the growth of prostate cancer in vitro and in vivo. Yu CH, Kan SF, Shu CH, Lu TJ, Sun-Hwang L, Wang PS. J Nutr Biochem. 2009 Oct;20(10):753-64. doi: 10.1016/j.jnutbio.2008.07.004. Epub 2008 Oct 16.