Cardiovascular

Hypercholesterolemia (cholesterol)

Effects of Agaricus blazei Murrill polysaccharides on hyperlipidemic rats by regulation of intestinal microflora.
Li Y, Lu X, Li X, Guo X, Sheng Y, Li Y, Xu G, Han X, An L, Du P. Food Sci Nutr. 2020 Apr 19;8(6):2758-2772. doi: 10.1002/fsn3.1568. eCollection 2020 Jun. PMID: 32566193

Isolation and purification of acidic polysaccharides from Agaricus blazei Murill and evaluation of their lipid-lowering mechanism. Li Y, Sheng Y, Lu X, Guo X, Xu G, Han X, An L, Du P. Int J Biol Macromol. 2020 Apr 25;157:276-287. doi: 10.1016/j.ijbiomac.2020.04.190. Online ahead of print. PMID: 32344083

Agaricus brasiliensis (sun mushroom) affects the expression of genes related to cholesterol homeostasis. de Miranda AM, Rossoni JĂșnior JV, Souza E Silva L, Dos Santos RC, Silva ME, Pedrosa ML. Eur J Nutr. 2016 May 5. [Epub ahead of print] PMID: 27151383

Aqueous Extract of Agaricus blazei Murrill Prevents Age-Related Changes in the Myenteric Plexus of the Jejunum in Rats. de Santi-Rampazzo AP, Schoffen JP, Cirilo CP, Zapater MC, Vicentini FA, Soares AA, Peralta RM, Bracht A, Buttow NC, Natali MR. Evid Based Complement Alternat Med. 2015;2015:287153. doi: 10.1155/2015/287153. Epub 2015 Apr 16. PMID: 25960748

Hypolipidemic effect of the edible mushroom Agaricus blazei in rats subjected to a hypercholesterolemic diet. de Miranda AM, Ribeiro GM, Cunha AC, Silva LS, dos Santos RC, Pedrosa ML, Silva ME. J Physiol Biochem. 2014 Mar;70(1):215-24. doi: 10.1007/s13105-013-0295-y. Epub 2013 Nov 8. PMID: 24203633

Hypertension (Blood Pressure)

Agaricus brasiliensis KA21 improves circulatory functions in spontaneously hypertensive rats. Tsubone H, Makimura Y, Hanafusa M, Yamamoto Y, Tsuru Y, Motoi M, Amano S. J Med Food. 2014 Mar;17(3):295-301. doi: 10.1089/jmf.2013.2934. Epub 2014 Jan 16. PMID: 24433071

A stable culturing method and pharmacological effects of the Agaricus blazei. Higaki M, Eguchi F, Watanabe Y. Nihon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:98P-103P. Japanese. PMID: 19503414