The Effect of Agaricus brasiliensis and Ganoderma lucidum Medicinal Mushroom Administration on the L-arginine/Nitric Oxide System and Rat Leukocyte Apoptosis in Experimental Type 1 Diabetes Mellitus. Yurkiv B, Wasser SP, Nevo E, Sybirna NO. Int J Med Mushrooms. 2015;17(4):339-50. PMID: 25954960

A stable culturing method and pharmacological effects of the Agaricus blazei. Higaki M, Eguchi F, Watanabe Y. Nihon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:98P-103P. Japanese. PMID: 9503414

Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus. Vitak T, Yurkiv B, Wasser S, Nevo E, Sybirna N. World J Diabetes. 2017 May 15;8(5):187-201. doi: 10.4239/wjd.v8.i5.187. Review.

Type 2

The beneficial effects of Agaricus blazei Murrill on hepatic antioxidant enzymes and the pancreatic tissue recovery in streptozotocin-induced diabetic rats. Wei Q, Huang L, Li J, Chen B, Xie B, Teng H, Chen L, Jiang Y. J Food Biochem. 2020 Mar 11:e13170. doi: 10.1111/jfbc.13170. [Epub ahead of print] PMID: 32160646

Enhancement of glucose homeostasis through the PI3K/Akt signaling pathway by dietary with Agaricus blazei Murrill in STZ-induced diabetic rats. Wei Q, Li J, Zhan Y, Zhong Q, Xie B, Chen L, Chen B, Jiang Y. Food Sci Nutr. 2020 Jan 13;8(2):1104-1114. doi: 10.1002/fsn3.1397. eCollection 2020 Feb. PMID: 32148819

Assessment of antioxidant and antidiabetic properties of Agaricus blazei Murill extracts. Wei Q, Zhan Y, Chen B, Xie B, Fang T, Ravishankar S, Jiang Y. Food Sci Nutr. 2019 Dec 5;8(1):332-339. doi: 10.1002/fsn3.1310. eCollection 2020 Jan. PMID: 31993159

Structural Changes of Erythrocyte Surface Glycoconjugates after Treatment with Medicinal Mushrooms. Vitak TY, Wasser SP, Nevo E, Sybirna NO. Int J Med Mushrooms. 2015;17(9):867-78. PMID: 26756299

Antioxidant Effects of Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Higher Basidiomycetes): Evidence from Animal Studies. Yurkiv B, Wasser SP, Nevo E, Sybirna NO. Int J Med Mushrooms. 2015;17(10):943-55. PMID: 26756186

The Effect of the Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Higher Basidiomycetes) on the Erythron System in Normal and Streptozotocin-Induced Diabetic Rats. Vitak TY, Wasser SP, Nevo E, Sybirna NO. Int J Med Mushrooms. 2015;17(3):277-86. PMID: 25954911

Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats. Ji W, Huang H, Chao J, Lu W, Guo J. Evid Based Complement Alternat Med. 2014;2014:679259. doi: 10.1155/2014/679259. Epub 2014 Jan 12. PMID: 24527050

The Medicinal Values of Culinary-Medicinal Royal Sun Mushroom (Agaricus blazei Murrill). Wang H, Fu Z, Han C. Evid Based Complement Alternat Med. 2013;2013:842619. doi: 10.1155/2013/842619. Epub 2013 Oct 31. Review. PMID: 24288568

The agaricoglyceride of royal sun medicinal mushroom, Agaricus brasiliensis (higher basidiomycetes) is anti-inflammatory and reverses diabetic glycemia in the liver of mice. Yu H, Han C, Sun Y, Qi X, Shi Y, Gao X, Zhang C. Int J Med Mushrooms. 2013;15(4):357-64. PMID: 23796217

Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats. Niwa A, Tajiri T, Higashino H. J Clin Biochem Nutr. 2011 May;48(3):194-202. doi: 10.3164/jcbn.10-78. Epub 2011 Jan 7. PMID: 21562638

Effect of Agaricus blazei Murill on the pulmonary tissue of animals with streptozotocin-induced diabetes. Di Naso FC, de Mello RN, Bona S, Dias AS, Porawski M, Ferraz Ade B, Richter MF, Marroni NP. Exp Diabetes Res. 2010;2010:543926. doi: 10.1155/2010/543926. Epub 2010 May 26. PMID: 20585363

Preparation, characterization, and biological properties of β-glucans. Rahar S, Swami G, Nagpal N, Nagpal MA, Singh GS. J Adv Pharm Technol Res. 2011 Apr;2(2):94-103. doi: 10.4103/2231-4040.82953. PMID: 22171300

The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P. J Altern Complement Med. 2007 Jan-Feb;13(1):97-102. PMID: 17309383

Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei. Kim YW, Kim KH, Choi HJ, Lee DS. Biotechnol Lett. 2005 Apr;27(7):483-7. PMID: 15928854

Effect of Agaricus brasiliensis S. Wasser et al. (Agarico-mycetideae) on Murine Diabetic Model C57BL/Ksj-db/db  Mai Furukawa, Noriko N. Miura, Yoshiyuki Adachi, Masuro Motoi, Naohito Ohno
pages 115-128  DOI: 10.1615/IntJMedMushr.v8.i2.30


Dietary supplementation with Agaricus blazei murill extract prevents diet-induced obesity and insulin resistance in rats. Vincent M, Philippe E, Everard A, Kassis N, Rouch C, Denom J, Takeda Y, Uchiyama S, Delzenne NM, Cani PD, Migrenne S, Magnan C. Obesity (Silver Spring). 2013 Mar;21(3):553-61. doi: 10.1002/oby.20276.

Metabolic Syndrome

Therapeutic properties of mushrooms in managing adverse effects in the metabolic syndrome. Kundaković T, Kolundžić M. Curr Top Med Chem. 2013;13(21):2734-44. Review. PMID: 24083790


 Royal Sun Culinary-Medicinal Mushroom Agaricus brasiliensis (Agaricomycetes) as a Functional Food in Gestational Diabetes Mellitus Before and After Fetus Implantation Erika Leão Ajala Caetano, Fabia Judice Marques Viroel, Leticia Favara Laurino, Isabella Ferreira Camargo, Raquel de Mendonça Rosa Castro, Thaisa Borim Pickler, Angela Faustino Jozala, Denise Grotto, Marli Gerenutti pages 15-27
DOI: 10.1615/IntJMedMushrooms.2021039797