Human Randomized Clinical Trials
Gynecological Cancer – Chemotherapy
Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP. Int J Gynecol Cancer. 2004 Jul-Aug;14(4):589-94. PMID: 15304151
Myeloma
Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study. Tangen JM, Tierens A, Caers J, Binsfeld M, Olstad OK, Trøseid AM, Wang J, Tjønnfjord GE, Hetland G. Biomed Res Int. 2015;2015:718539. doi: 10.1155/2015/718539. Epub 2015 Jan 18. PMID: 25664323
Crohn’s Disease & Ulcerative Colitis
Cytokine Levels After Consumption of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™ , in Patients with Crohn’s Disease and Ulcerative Colitis in a Randomized Single-Blinded Placebo-Controlled Study. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Scand J Immunol. 2016 Dec;84(6):323-331. doi: 10.1111/sji.12476. PMID: 27588816
Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Crohn’s Disease in a Randomized Single-Blinded Placebo Controlled Study. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. PLoS One. 2016 Jul 14;11(7):e0159288. doi: 10.1371/journal.pone.0159288. eCollection 2016. PMID: 27415795
Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. PLoS One. 2016 Mar 2;11(3):e0150191. doi: 10.1371/journal.pone.0150191. eCollection 2016. PMID: 26933886
Diabetes
The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P. J Altern Complement Med. 2007 Jan-Feb;13(1):97-102. PMID: 17309383
Hepatitis B
The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. Hsu CH, Hwang KC, Chiang YH, Chou P. J Altern Complement Med. 2008 Apr;14(3):299-301. doi: 10.1089/acm.2006.6344. PMID: 18370584
Physical Training
Royal Sun Culinary-Medicinal Mushroom, Agaricus brasiliensis (Agaricomycetes), Supplement in Training Capacity Improvement Parameters. Silva FF, de Oliveira GAC, Costa HCM, Regis WCB. Int J Med Mushrooms. 2017;19(9):759-766. doi: 10.1615/IntJMedMushrooms.2017024386. PMID: 29199551