Anti-Mutagenic & Anti-Metastatic

Possible reduction of hepatoma formation by Smmu 7721 cells in SCID mice and metastasis formation by B16F10 melanoma cells in C57BL/6 mice by Agaricus blazei murill extract. Wu MF, Lu HF, Hsu YM, Tang MC, Chen HC, Lee CS, Yang YY, Yeh MY, Chung HK, Huang YP, Wu CC, Chung JG. In Vivo. 2011 May-Jun;25(3):399-404. PMID: 21576414

A low molecular weight polysaccharide isolated from Agaricus blazei Murill (LMPAB) exhibits its anti-metastatic effect by down-regulating metalloproteinase-9 and up-regulating Nm23-H1. Niu YC, Liu JC, Zhao XM, Cao J. Am J Chin Med. 2009;37(5):909-21. PMID: 19885951

Cytotoxicity, genotoxicity and antimutagenicity of hexane extracts of Agaricus blazei determined in vitro by the comet assay and CHO/HGPRT gene mutation assay. Machado MP, Filho ER, Terezan AP, Ribeiro LR, Mantovani MS. Toxicol In Vitro. 2005 Jun;19(4):533-9. PMID: 15826811

Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model. Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yagyu T, Inagaki K, Kondo T, Kurita N, Suzuki M, Kanayama N, Terao T. J Cancer Res Clin Oncol. 2005 Aug;131(8):527-38. Epub 2005 May 10. PMID: 15883813

Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions. Kimura Y, Kido T, Takaku T, Sumiyoshi M, Baba K. Cancer Sci. 2004 Sep;95(9):758-64. PMID: 15471563

Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide. Delmanto RD, de Lima PL, Sugui MM, da Eira AF, Salvadori DM, Speit G, Ribeiro LR. Mutat Res. 2001 Sep 20;496(1-2):15-21. PMID: 11551476

Antimutagenic effects of the mushroom Agaricus blazei Murrill extracts on V79 cells. Menoli RC, Mantovani MS, Ribeiro LR, Speit G, Jordão BQ. Mutat Res. 2001 Sep 20;496(1-2):5-13. PMID: 11551475

[Antimutagenic and bactericidal substances in the fruit body of a Basidiomycete Agaricus blazei, Jun-17]. Osaki Y, Kato T, Yamamoto K, Okubo J, Miyazaki T. Yakugaku Zasshi. 1994 May;114(5):342-50. Japanese. PMID: 8014843

Medicinal Properties and Clinical Effects of Culinary-Medicinal Mushroom Agaricus blazei Murrill (Agaricomycetideae) (Review) Takashi Mizuno Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 4-13-9 Seinan-Cho, Fujieda-Shi 426-0063, Japan DOI: 10.1615/IntJMedMushr.v4.i4.30