Anti-Tumor

The polar high molecular weight fraction of the Agaricus blazei Murill extract, AndoSan™, reduces the activity of the tumor-associated protease, legumain, in RAW 264.7 cells. Berven L, Karppinen P, Hetland G, Samuelsen AB. J Med Food. 2015 Apr;18(4):429-38. doi: 10.1089/jmf.2014.0018. Epub 2014 Aug 19. PMID: 25136950

 Polysaccharide Agaricus blazei Murill stimulates myeloid derived suppressor cell differentiation from M2 to M1 type, which mediates inhibition of tumour immune-evasion via the Toll-like receptor 2 pathway. Liu Y, Zhang L, Zhu X, Wang Y, Liu W, Gong W. Immunology. 2015 Nov;146(3):379-91. doi: 10.1111/imm.12508. Epub 2015 Sep 3. PMID: 26194418

 Agaricus bisporus and Agaricus brasiliensis (1→6)-β-D-glucans show immunostimulatory activity on human THP-1 derived macrophages. Smiderle FR, Alquini G, Tadra-Sfeir MZ, Iacomini M, Wichers HJ, Van Griensven LJ. Carbohydr Polym. 2013 Apr 15;94(1):91-9. doi: 10.1016/j.carbpol.2012.12.073. Epub 2013 Jan 16. PMID: 23544515

 Macrophage activation-mediated hydrogen peroxide generation by the royal sun medicinal mushroom Agaricus brasiliensis (Higher Basidiomycetes). Mizuno M, Nishitani Y. Int J Med Mushrooms. 2013;15(4):365-71. PMID: 23796218

 The anti-tumorigenic mushroom Agaricus blazei Murill enhances IL-1β production and activates the NLRP3 inflammasome in human macrophages. Huang TT, Ojcius DM, Young JD, Wu YH, Ko YF, Wong TY, Wu CY, Lu CC, Lai HC. PLoS One. 2012;7(7):e41383. doi: 10.1371/journal.pone.0041383. Epub 2012 Jul 23. PMID: 22844468

 The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation. Hetland G, Johnson E, Lyberg T, Kvalheim G. Adv Pharmacol Sci. 2011;2011:157015. doi: 10.1155/2011/157015. Epub 2011 Sep 6. PMID: 21912538

 Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells. Endo M, Beppu H, Akiyama H, Wakamatsu K, Ito S, Kawamoto Y, Shimpo K, Sumiya T, Koike T, Matsui T. Biochim Biophys Acta. 2010 Jul;1800(7):669-73. doi: 10.1016/j.bbagen.2010.03.016. Epub 2010 Mar 27. PMID: 20347942

 Effects of Agaricus brasiliensis mushroom in Walker-256 tumor-bearing rats. Jumes FM, Lugarini D, Pereira AL, de Oliveira A, Christoff Ade O, Linde GA, do Valle JS, Colauto NB, Acco A. Can J Physiol Pharmacol. 2010 Jan;88(1):21-7. doi: 10.1139/Y09-111. PMID: 20130735

 Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice. Niu YC, Liu JC, Zhao XM, Su FQ, Cui HX. Pharmazie. 2009 Jul;64(7):472-6. PMID: 19694186

In vivo growth-inhibition of Sarcoma 180 by an alpha-(1–>4)-glucan-beta-(1–>6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill. Gonzaga ML, Bezerra DP, Alves AP, de Alencar NM, Mesquita Rde O, Lima MW, Soares Sde A, Pessoa C, de Moraes MO, Costa-Lotufo LV. J Nat Med. 2009 Jan;63(1):32-40. doi: 10.1007/s11418-008-0286-4. Epub 2008 Aug 23. PMID: 18726068

 Polysaccharide fraction of Agaricus brasiliensis avoids tumor-induced IL-10 production and changes the microenvironment of subcutaneous Ehrlich adenocarcinoma. Pinto AV, Martins PR, Romagnoli GG, Campanelli AP, Terezan AP, Filho ER, Ferreira da Eira A, Kaneno R. Cell Immunol. 2009;256(1-2):27-38. doi: 10.1016/j.cellimm.2009.01.002. Epub 2009 Feb 24. PMID: 19243740

 Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricus blazei extracts. Takimoto H, Kato H, Kaneko M, Kumazawa Y. Immunopharmacol Immunotoxicol. 2008;30(4):747-60. doi: 10.1080/08923970802279092 . PMID: 18720167

 Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model. Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yagyu T, Inagaki K, Kondo T, Kurita N, Suzuki M, Kanayama N, Terao T. J Cancer Res Clin Oncol. 2005 Aug;131(8):527-38. Epub 2005 May 10. PMID: 15883813

New anticancer agents: in vitro and in vivo evaluation of the antitumor and antimetastatic actions of various compounds isolated from medicinal plants. Kimura Y. In Vivo. 2005 Jan-Feb;19(1):37-60. Review. PMID: 15796155

Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model. Lee YL, Kim HJ, Lee MS, Kim JM, Han JS, Hong EK, Kwon MS, Lee MJ. Exp Anim. 2003 Oct;52(5):371-5. PMID: 14625400

 [Activation of antitumor immunity by intratumor injection of biological preparations]. Ebina T. Gan To Kagaku Ryoho. 2003 Oct;30(11):1555-8. Japanese.  PMID: 14619462

Enhanced shear protection and increased production of an anti-tumor polysaccharide by Agaricus blazei in xanthan-supplemented cultures. Shu CH, Wen BJ. Biotechnol Lett. 2003 Jun;25(11):873-6. PMID: 12889797

Orally administered beta-1,6-D-polyglucose extracted from Agaricus blazei results in tumor regression in tumor-bearing mice. Oshiman K, Fujimiya Y, Ebina T, Suzuki I, Noji M. Planta Med. 2002 Jul;68(7):610-4. PMID: 12142994

 Antitumor beta glucan from the cultured fruit body of Agaricus blazei. Ohno N, Furukawa M, Miura NN, Adachi Y, Motoi M, Yadomae T. Biol Pharm Bull. 2001 Jul;24(7):820-8. PMID: 11456124

 Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide. Delmanto RD, de Lima PL, Sugui MM, da Eira AF, Salvadori DM, Speit G, Ribeiro LR. Mutat Res. 2001 Sep 20;496(1-2):15-21. PMID: 11551476

 Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. Takaku T, Kimura Y, Okuda H. J Nutr. 2001 May;131(5):1409-13. PMID: 11340091

Medicinal Properties and Clinical Effects of Culinary-Medicinal Mushroom Agaricus blazei Murrill (Agaricomycetideae) (Review) Takashi Mizuno  Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 4-13-9 Seinan-Cho, Fujieda-Shi 426-0063, Japan DOI:10.1615/IntJMedMushr.v4.i4.308.

Inhibitory activity of polysaccharide extracts from three kinds of edible fungi on proliferation of human hepatoma SMMC-7721 cell and mouse implanted S180 tumor. Jiang SM, Xiao ZM, Xu ZH. World J Gastroenterol. 1999 Oct;5(5):404-407. PMID: 11819477

 Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei mill. Mizuno M, Minato K, Ito H, Kawade M, Terai H, Tsuchida H. Biochem Mol Biol Int. 1999 Apr;47(4):707-14. PMID: 10319424

 Tumor-specific cytocidal and immunopotentiating effects of relatively low molecular weight products derived from the basidiomycete, Agaricus blazei Murill. Fujimiya Y, Suzuki Y, Katakura R, Ebina T. Anticancer Res. 1999 Jan-Feb;19(1A):113-8. PMID: 10226531

 Antitumor effect of a peptide-glucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice. Ebina T, Fujimiya Y. Biotherapy. 1998;11(4):259-65. PMID: 9950102

 Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis. Fujimiya Y, Suzuki Y, Oshiman K, Kobori H, Moriguchi K, Nakashima H, Matumoto Y, Takahara S, Ebina T, Katakura R. Cancer Immunol Immunother. 1998 May;46(3):147-59. PMID: 9625538

 Antitumor effects of a new polysaccharide-protein complex (ATOM) prepared from Agaricus blazei (Iwade strain 101) “Himematsutake” and its mechanisms in tumor-bearing mice. Ito H, Shimura K, Itoh H, Kawade M. Anticancer Res. 1997 Jan-Feb;17(1A):277-84. PMID: 9066665

 Inhibitory action of a (1–>6)-beta-D-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murill (“himematsutake”) on Meth A fibrosarcoma-bearing mice and its antitumor mechanism. Itoh H, Ito H, Amano H, Noda H. Jpn J Pharmacol. 1994 Oct;66(2):265-71. PMID: 7869611

 Fractionation and antitumor activity of the water-insoluble residue of Agaricus blazei fruiting bodies. Kawagishi H, Inagaki R, Kanao T, Mizuno T, Shimura K, Ito H, Hagiwara T, Nakamura T. Carbohydr Res. 1989 Mar 15;186(2):267-73. PMID: 2736561