Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity. Lu CC, Hsu YJ, Chang CJ, Lin CS, Martel J, Ojcius DM, Ko YF, Lai HC, Young JD. Innate Immun. 2016 Oct;22(7):522-33. doi: 10.1177/1753425916661402. Epub 2016 Jul 28. PMID: 27469258

Polysaccharide Agaricus blazei Murill stimulates myeloid derived suppressor cell differentiation from M2 to M1 type, which mediates inhibition of tumour immune-evasion via the Toll-like receptor 2 pathway. Liu Y, Zhang L, Zhu X, Wang Y, Liu W, Gong W. Immunology. 2015 Nov;146(3):379-91. doi: 10.1111/imm.12508. Epub 2015 Sep 3. PMID: 26194418

Extract of medicinal mushroom Agaricus blazei Murill enhances the non-specific and adaptive immune activities in BALB/c mice. Ni WY, Wu MF, Liao NC, Yeh MY, Lu HF, Hsueh SC, Liu JY, Huang YP, Chang CH, Chung JG. In Vivo. 2013 Nov-Dec;27(6):779-86. PMID: 24292582

An extract of Agaricus blazei Murill administered orally promotes immune responses in murine leukemia BALB/c mice in vivo. Lin JG, Fan MJ, Tang NY, Yang JS, Hsia TC, Lin JJ, Lai KC, Wu RS, Ma CY, Wood WG, Chung JG. Integr Cancer Ther. 2012 Mar;11(1):29-36. doi: 10.1177/1534735411400314. PMID: 22637937

Effects of Agaricus blazei Murill extract on immune responses in normal BALB/c mice. Tang NY, Yang JS, Lin JP, Hsia TC, Fan MJ, Lin JJ, Weng SW, Ma YS, Lu HF, Shen JJ, Lin JG, Chung JG. In Vivo. 2009 Sep-Oct;23(5):761-6. PMID: 19779112

Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice. Niu YC, Liu JC, Zhao XM, Su FQ, Cui HX. Pharmazie. 2009 Jul;64(7):472-6. PMID: 19694186

Lack of chemopreventive activity of Agaricus blazei mushroom on the development of 1,2-dimethylhydrazine-induced colonic aberrant crypt foci in rats. Ribeiro-Santos G, Barbisan LF, Lopes FC, Spinardi-Barbisan AL, da Eira AF, Kaneno R. Nutr Cancer. 2008;60(6):768-75. doi: 10.1080/01635580802196115. PMID: 19005976

Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers. Liu Y, Fukuwatari Y, Okumura K, Takeda K, Ishibashi K, Furukawa M, Ohno N, Mori K, Gao M, Motoi M. Evid Based Complement Alternat Med. 2008 Jun;5(2):205-19. doi: 10.1093/ecam/nem016. PMID: 18604247

Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill. Yuminamochi E, Koike T, Takeda K, Horiuchi I, Okumura K. Immunology. 2007 Jun;121(2):197-206. Epub 2007 Mar 7. PMID: 17346284

In vitro augmentation of natural killer activity and interferon-gamma production in murine spleen cells with Agaricus blazei fruiting body fractions. Zhong M, Tai A, Yamamoto I. Biosci Biotechnol Biochem. 2005 Dec;69(12):2466-9. PMID: 16377912

IL-12 Production Induced by Agaricus blazei Fraction H (ABH) Involves Toll-like Receptor (TLR). Kasai H, He LM, Kawamura M, Yang PT, Deng XW, Munkanta M, Yamashita A, Terunuma H, Hirama M, Horiuchi I, Natori T, Koga T, Amano Y, Yamaguchi N, Ito M. Evid Based Complement Alternat Med. 2004 Dec;1(3):259-267. PMID: 15841259

Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions. Kimura Y, Kido T, Takaku T, Sumiyoshi M, Baba K. Cancer Sci. 2004 Sep;95(9):758-64. PMID: 15471563

Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP. Int J Gynecol Cancer. 2004 Jul-Aug;14(4):589-94. PMID: 15304151

Effects of extracts from Brazilian sun-mushroom (Agaricus blazei) on the NK activity and lymphoproliferative responsiveness of Ehrlich tumor-bearing mice. Kaneno R, Fontanari LM, Santos SA, Di Stasi LC, Rodrigues Filho E, Eira AF. Food Chem Toxicol. 2004 Jun;42(6):909-16. PMID: 15110099

Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis. Fujimiya Y, Suzuki Y, Oshiman K, Kobori H, Moriguchi K, Nakashima H, Matumoto Y, Takahara S, Ebina T, Katakura R. Cancer Immunol Immunother. 1998 May;46(3):147-59. PMID: 9625538