Leishmaniases – An infection with leishmania a protozoan parasite spread by sandflies. For more information on leishmaniases

Evaluation of adjuvant activity of fractions derived from Agaricus blazei, when in association with the recombinant LiHyp1 protein, to protect against visceral leishmaniasis. de Jesus Pereira NC, Régis WC, Costa LE, de Oliveira JS, da Silva AG, Martins VT, Duarte MC, de Souza JR, Lage PS, Schneider MS, Melo MN, Soto M, Soares SA, Tavares CA, Chávez-Fumagalli MA, Coelho EA.Exp Parasitol. 2015 Jun;153:180-90. doi: 10.1016/j.exppara.2015.03.027. Epub 2015 Apr 3.

Prophylactic or therapeutic administration of Agaricus blazei Murill is effective in treatment of murine visceral leishmaniasis. Valadares DG, Duarte MC, Ramírez L, Chávez-Fumagalli MA, Martins VT, Costa LE, Lage PS, Ribeiro TG, Castilho RO, Fernandes AP, Régis WC, Soto M, Tavares CA, Coelho EA. Exp Parasitol. 2012 Oct;132(2):228-36. doi: 10.1016/j.exppara.2012.07.005. Epub 2012 Jul 20.

Therapeutic efficacy induced by the oral administration of Agaricus blazei Murill against Leishmania amazonensis. Valadares DG, Duarte MC, Ramírez L, Chávez-Fumagalli MA, Lage PS, Martins VT, Costa LE, Ribeiro TG, Régis WC, Soto M, Fernandes AP, Tavares CA, Coelho EA. Parasitol Res. 2012 Oct;111(4):1807-16. Epub 2012 Jul 15.

Leishmanicidal activity of the Agaricus blazei Murill in different Leishmania species. Valadares DG, Duarte MC, Oliveira JS, Chávez-Fumagalli MA, Martins VT, Costa LE, Leite JP, Santoro MM, Régis WC, Tavares CA, Coelho EA. Parasitol Int. 2011 Dec;60(4):357-63. doi: 10.1016/j.parint.2011.06.001. Epub 2011 Jun 24.


MalariaSerious disease caused by a parasite when an infected mosquito bites a person. There are more than a 100 different malaria parasites but the most deadly and common are in Africa (Plasmodium falciparum). It is a major cause of death worldwide.

Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria. Val CH1, Brant F2,3, Miranda AS4, Rodrigues FG5, Oliveira BC6, Santos EA7, Assis DR8, Esper L9,10, Silva BC11, Rachid MA12, Tanowitz HB13, Teixeira AL14, Teixeira MM15,16, Régis WC17, Machado FS18,19. PLoS One. 2016 Mar 2;11(3):e0150191. doi: 10.1371/journal.pone.0150191. eCollection 2016.

N-acetyl cysteine and mushroom Agaricus sylvaticus supplementation decreased parasitaemia and pulmonary oxidative stress in a mice model of malaria. Quadros Gomes BA, da Silva LF, Quadros Gomes AR, Moreira DR, Dolabela MF, Santos RS, Green MD, Carvalho EP, Percário S. Malar J. 2015 May 15;14:202. doi: 10.1186/s12936-015-0717-0.


Nosema Ceranae

Potential of Fumagillin and Agaricus blazei Mushroom Extract to Reduce Nosema ceranae in Honey Bees.
Glavinic U, Stevanovic J, Ristanic M, Rajkovic M, Davitkov D, Lakic N, Stanimirovic Z. Insects. 2021 Mar 25;12(4):282. doi: 10.3390/insects12040282. PMID: 33806001

Schistosoma mansoni

Immunopathological effects of Agaricus blazei Murill polysaccharides against Schistosoma mansoni infection by Th1 and NK1 cells differentiation.Lin MH, Lee KM, Hsu CY, Peng SY, Lin CN, Chen CC, Fan CK, Cheng PC.
Int Immunopharmacol. 2019 Aug;73:502-514. doi: 10.1016/j.intimp.2019.05.045. Epub 2019 Jun 4. PMID: 31173972