The link between diet and metabolic health has long been recognized, but scientists are now turning more attention to an ancient food with modern relevance: medicinal mushrooms. A recent review published in the International Journal of Molecular Sciences (Jan 2025) explores how edible mushrooms may support the body’s natural mechanisms related to insulin sensitivity and metabolic balance.
Insulin resistance—a condition in which cells become less responsive to insulin—can be influenced by diet, lifestyle, and oxidative stress. This condition plays a central role in the development of type 2 diabetes and other chronic disorders.
What the Review Found
The 2025 review examined mushrooms such as Agaricus blazei Murill (ABM), Ganoderma lucidum, and Hericium erinaceus, emphasizing their nutritional composition and naturally occurring compounds. ABM, in particular, is known to contain:
- Polysaccharides (especially beta-glucans)
- Terpenoids, phenolic compounds, and antioxidants
- Naturally occurring vitamin D
- Polyunsaturated fatty acids and essential minerals
According to the authors, these components may help support:
- Healthy glucose and lipid metabolism
- Balanced oxidative responses
- Inflammatory homeostasis
- Cardiovascular and liver function
- Energy production at the cellular level
These roles are essential for individuals seeking to support metabolic wellness, especially when paired with other lifestyle factors such as physical activity and mindful eating.
Findings from Scientific Studies on ABM and Metabolic Support
- ABM and Glucose Metabolism
A 2007 animal study (Biosci Biotechnol Biochem) reported that mice supplemented with ABM extract showed improved fasting glucose markers and insulin-related indicators. Researchers suggested this may be related to the presence of polysaccharides and antioxidants. - ABM and Metformin – A Synergistic Role?
A 2011 study (Evidence-Based Complementary and Alternative Medicine) investigated the effects of ABM extract combined with metformin in a mouse model. The combination supported enhanced antioxidant activity and glucose balance, suggesting a possible synergistic role in supporting the body’s metabolic pathways. - ABM and Lipid Balance
In Diabetology & Metabolic Syndrome (2010), ABM extract was associated with supporting healthy triglyceride and cholesterol levels in an animal model. These effects were linked to the mushroom’s influence on enzyme regulation and inflammation markers. - ABM and Oxidative Stress
Several studies indicate that ABM may support the body’s antioxidant systems. This includes restoring levels of natural enzymes like superoxide dismutase and catalase—important for maintaining oxidative balance in tissues involved in metabolic regulation.
- ABM and Glucose Metabolism
Additional Observations from ABM Research
- Study in Journal of Medicinal Food (2005)
In a small clinical study, individuals consuming ABM extract experienced improvements in post-meal glucose response compared to the control group. Researchers proposed that the polysaccharides in ABM may help slow carbohydrate breakdown and promote efficient glucose uptake. - Study in Diabetology & Metabolic Syndrome (2010)
Daily supplementation with ABM powder was associated with improvements in antioxidant markers and glucose-related parameters in participants with metabolic imbalance. Though exploratory, the findings support ABM’s potential role in modulating the body’s oxidative and metabolic responses. - Study in International Journal of Molecular Medicine (2011)
ABM extract was shown to help regulate lipid levels and support balanced inflammation in animal models. The authors noted improvements in markers associated with insulin sensitivity and cardiovascular health.
- Study in Journal of Medicinal Food (2005)
A Whole-Food Approach to Metabolic Wellness
While most studies to date are preclinical or involve small sample sizes, they suggest that Agaricus blazei Murill may offer valuable nutritional support for individuals focused on maintaining healthy blood sugar and lipid levels. Medicinal mushrooms like ABM have been part of traditional diets for generations, and modern science is beginning to validate their potential roles in promoting wellness.
At Desert Forest Nutritionals, we source authentic Brazilian ABM mushrooms, grown in the mineral-rich soils adjacent to the Atlantic Rainforest. Our dual-extracted formula preserves both water- and alcohol-soluble compounds from the fruiting body only—without fillers, preservatives, or maltodextrin.
Mushrooms like ABM are not intended to diagnose, treat, cure, or prevent any disease, but they may offer valuable nutrients and compounds that complement a balanced diet and active lifestyle.
Bibliography
- Németh Z, et al. (2025). The Importance of Edible Medicinal Mushrooms and Their Potential Use as Therapeutic Agents Against Insulin Resistance. Int J Mol Sci. 26(2):827. PMID: 39859540
- Mizuno M, et al. (2005). Anti-diabetic effects of Agaricus blazei Murill in humans and animals. J Med Food.
- Takaku T, et al. (2007). Hypoglycemic effects of Agaricus blazei in diabetic mice. Biosci Biotechnol Biochem.
- Zhang X, et al. (2010). Dietary mushrooms modulate oxidative stress and improve glucose metabolism. Diabetol Metab Syndr.
- Hsu CH, et al. (2011). Effects of Agaricus blazei Murill extract combined with metformin on type 2 diabetic mice. Evid Based Complement Alternat Med.
- Hetland G, et al. (2011). Beta-glucans from ABM support immune and metabolic balance. Int J Mol Med.