Gut Health and Digestive Comfort

Gut-Immune Interaction and Digestive Comfort Support

Cytokine Levels After Consumption of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan , in Patients with Crohn’s Disease and Ulcerative Colitis in a Randomized Single-Blinded Placebo-Controlled Study. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Scand J Immunol. 2016 Dec;84(6):323-331. doi: 10.1111/sji.12476. PMID: 27588816

Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSanTM, on Symptoms, Fatigue and Quality of Life in Patients with Crohn’s Disease in a Randomized Single-Blinded Placebo Controlled Study. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. PLoS One. 2016 Jul 14;11(7):e0159288. doi: 10.1371/journal.pone.0159288. eCollection 2016. PMID: 27415795

Extract of medicinal mushroom Agaricus blazei Murill enhances the non-specific and adaptive immune activities in BALB/c mice. Ni WY, Wu MF, Liao NC, Yeh MY, Lu HF, Hsueh SC, Liu JY, Huang YP, Chang CH, Chung JG. In Vivo. 2013 Nov-Dec;27(6):779-86. PMID: 24292582

Effect of an extract based on the medicinal mushroom Agaricus blazei Murill on expression of cytokines and calprotectin in patients with ulcerative colitis and Crohn‘s disease. Førland DT, Johnson E, Saetre L, Lyberg T, Lygren I, Hetland G. Scand J Immunol. 2011 Jan;73(1):66-75. doi: 10.1111/j.1365-3083.2010.02477.x.

Microbiome and Metabolic Pathway Modulation

Traditional Chinese Medicine in Osteoporosis Intervention and the Related Regulatory Mechanism of Gut Microbiome. Li K, Jiang Y, Wang N, Lai L, Xu S, Xia T, Yue X, Xin H. Am J Chin Med. 2023 Oct 27:1-25. doi: 10.1142/S0192415X23500866. Online ahead of print. PMID: 37884447

Gastroprotective Activity for Stomach Comfort

Gastroprotective effect of hydroalcoholic extract from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice.
Câmara Neto JF, Campelo MDS, Cerqueira GS, de Miranda JAL, Guedes JAC, de Almeida RR, Soares SA, Gramosa NV, Zocolo GJ, Vieira ÍGP, Ricardo NMPS, Ribeiro MENP. J Ethnopharmacol. 2022 Mar 12;292:115191. doi: 10.1016/j.jep.2022.115191. Online ahead of print. PMID: 35292374

Intestinal Barrier and Mucosal Integrity Support

Agaricus blazei Polysaccharide Alleviates DSS-Induced Colitis in Mice by Modulating Intestinal Barrier and Remodeling Metabolism.
Ji ZH, He S, Xie WY, Zhao PS, Ren WZ, Gao W, Yuan B. Nutrients. 2023 Nov 22;15(23):4877. doi: 10.3390/nu15234877. PMID: 38068735

Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. PLoS One. 2016 Mar 2;11(3):e0150191. doi: 10.1371/journal.pone.0150191. eCollection 2016. PMID: 26933886